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Antimicrobial activity of linezolid against Gram-positive cocci isolated in Brazil BJID
Sader,Helio S.; Gales,Ana C.; Jones,Ronald N..
The new oxazolidinone linezolid and other antimicrobial agents used to treat Gram-positive infections were tested against 1,585 Gram-positive cocci; 1,260 staphylococci and enterococci isolates from patients hospitalized in Brazilian hospitals, and 325 S. pneumoniae isolates for patients with community acquired infections. Susceptibility testing was performed using broth microdilution according to NCCLS procedures. Linezolid was the most active compound and the only drug that inhibited 100% of the isolates at the susceptible breakpoint (< 4 mg/mL). Resistance to vancomycin was very rare (99.9% susceptibility), and both quinupristin/dalfopristin and gatifloxacin were active against approximately 90% of the strains evaluated. All other compounds inhibited...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gram-positive cocci; Oxazolidinones; Antimicrobial resistance; Linezolid; Vancomycin resistance; Nosocomial infections.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400002
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Antimicrobial resistance and plasmid replicons in Yersinia enterocolitica strains isolated in Brazil in 30 years BJID
Frazão,Miliane R.; Andrade,Leonardo N.; Darini,Ana L.C.; Falcão,Juliana P..
Abstract Some studies evaluated the resistance profile of the Y. enterocolitica strains isolated in diverse countries. However, in Brazil the isolation and the study of Y. enterocolitica are not common and therefore information about the antimicrobial resistance profile of this species in this country is scarce. Therefore, the aim of this study was to evaluate the antimicrobial resistance of Y. enterocolitica of biotypes 1A, 2 and 4 isolated from clinical and non-clinical sources between 1979 and 2012, in Brazil. This study showed that some Yersinia enterocolitica of different biotypes remain susceptible to antimicrobials used for gastroenteritis treatment. Moreover, neither acquired resistance genes nor diversity of plasmids replicons were found; however,...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Yersinia enterocolitica; Resistance profile; Plasmid replicon.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400477
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Antimicrobial resistance in respiratory pathogens isolated in Brazil during 1999-2000 BJID
Critchley,Ian A.; Blosser,Renée S.; Karlowsky,James A.; Yamakita,Juri; Barth,Alfonso; Sader,Helio S.; Mendes,Caio; Teixeira,Lucia; Rossi,Flavia; Dias,Cicero A. C.; Jones,Mark E.; Thornsberry,Clyde; Sahm,Daniel F..
The in vitro antimicrobial susceptibility of the respiratory pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis to commonly tested and prescribed agents was investigated during 1999-2000 and compared with results obtained during a previous 1997-1998 study. Of 448 isolates of S. pneumoniae collected and tested in 1999-2000, 77.2% were susceptible, 19.9% were intermediate, and 2.9% were resistant to penicillin, demonstrating that there were no major changes in susceptibility to penicillin from 1997-1998 (77.1% susceptible, 18.7% intermediate, 4.2% resistant). All S. pneumoniae isolates from 1999-2000 were susceptible to levofloxacin and vancomycin, and >90% were susceptible to the beta-lactams (amoxicillin-clavulanate,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptococcus pneumoniae; Antimicrobial resistance; Surveillance study; Respiratory pathogen.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600002
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Antimicrobial resistance of clinical and environmental strains of Vibrio cholerae isolated in Lima-Peru during epidemics of 1991 and 1998 BJID
Ibarra,J.O.; Alvarado,D.E..
The susceptibility in vitro of 71 isolations of V. cholerae was evaluated: 24 of clinical origin and 47 strains of clinical and environmental origin collected in the epidemic of 1991 and during the outbreak epidemic of 1998 in Lima-Peru respectively. The biochemical and serological tests carried out established that 43 (60,6%) corresponded to the serogroup O1 Ogawa of the 1998 epidemic; 26 (36.6%) were of the serotype Inaba, being 24 of them isolated in 1991. Two strains did not belong to the serogroup O1. By means of disk diffusion method and Minimal Inhibitory Concentration (MIC), 15 strains with multi-resistance to antibiotics were determined, 10 of which were of clinical origin and 5 of natural origin, showing 9 antibiotypes with different resistance...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vibrio cholerae; Antimicrobial resistance; Cholera outbreak.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100022
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Antimicrobial resistance of Pseudomonas aeruginosa in a Romanian hospital at the dawn of multidrug resistance BJID
Gavriliu,Liana-Catalina; Popescu,Gabriel-Adrian; Popescu,Cristina.
Tipo: Info:eu-repo/semantics/other
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500509
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Antimicrobial resistance profile of pathogens isolated from blood cultures in public and private hospitals in Brazil BJID
Fleming,Maria Emília Castro Kling de; Paula,Geraldo Renato de; Carballido,Jupira Miron; Mondino,Pedro Juan Jose; Barros,Rosana Rocha.
Tipo: Info:eu-repo/semantics/other
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500024
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Antimicrobial susceptibility associated with bloodstream infections in children: a referral hospital-based study BJID
Ashtiani,Mohammad Taghi Haghi; Mamishi,Setareh; Masoomi,Ahmad; Nasiri,Nafiseh; Hosseini,Mohammad; Nikmanesh,Bahram; Pourakbari,Babak; Rezaei,Nima.
Tipo: Info:eu-repo/semantics/other
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400020
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Antimicrobial susceptibility in intensive care units: MYSTIC Program Brazil 2002 BJID
Mendes,Caio; Oplustil,Carmen; Sakagami,Elsa; Turner,Philip; Kiffer,Carlos.
OBJECTIVE: Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2002. MATERIAL AND METHODS: Gram-negative bacteria (n = 503) causing nosocomial infections were collected at seven Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by E-test methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). RESULTS: Pseudomonas aeruginosa (33%) was the most frequently isolated, followed by A. baumannii (17.1%), K. pneumoniae...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100008
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Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion BJID
Fraga,Edmir Geraldo; Nicodemo,Antonio Carlos; Sampaio,Jorge Luiz Mello.
Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clostridium difficile; Disk diffusion; Agar dilution; Susceptibility testing.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500476
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Antimicrobial susceptibility of Gram-negative bacteria in Brazilian hospitals: the MYSTIC Program Brazil 2003 BJID
Kiffer,Carlos; Hsiung,Andre; Oplustil,Carmen; Sampaio,Jorge; Sakagami,Elsa; Turner,Philip; Mendes,Caio.
Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2003. Gram-negative bacteria (n = 1,550) causing nosocomial infections were collected at 20 Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by Etest methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). Pseudomonas aeruginosa (30.3%) was the most frequent isolate, followed by E. coli (18.6%), Klebsiella pneumoniae (16.9%), Acitenobacter baumannii (8.8%), and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300004
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Antimicrobial susceptibility of gram-positive bacteria isolated in brazilian hospitals participating in the SENTRY Program (2005-2008) BJID
Gales,Ana C.; Sader,Helio S.; Ribeiro,Julival; Zoccoli,Cassia; Barth,Afonso; Pignatari,Antonio C..
We report the antimicrobial susceptibility patterns of the most frequently isolated Gram-positive bacteria in the Brazilian hospitals participating in the SENTRYAntimicrobial Surveillance Program. The strains were consecutively collected (one per patient) between January 2005 and September 2008 and susceptibility tested by reference broth microdilution methods at the JMI Laboratories (North Liberty, Iowa, USA). A total of 3,907 Gram-positive cocci were analyzed. The Gram-positive organisms most frequently isolated from bloodstream infections were Staphylococcus aureus (2,218 strains; 20.2% of total), coagulase-negative staphylococci (CoNS; 812 strains [14.7%]), and Enterococcus spp. (754 strains; 5.0%). S. aureus ranked first (28.1%) and Enterococcus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobial resistance; SENTRY; Nosocomial infections; Brazil.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200004
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Antimicrobial susceptibility of hospital acquired Stenotrophomonas maltophilia isolate biofilms BJID
Sun,Erlin; Liang,Gehong; Wang,Lining; Wei,Wenjie; Lei,Mingde; Song,Shiduo; Han,Ruifa; Wang,Yubao; Qi,Wei.
Abstract Aims We sought to characterize the antibiotic susceptibility of strains of Stenotrophomonas maltophilia isolated from clinical samples, and the role of Stenotrophomonas maltophilia biofilm in antibiotic resistance. Methods Fifty-one clinical Stenotrophomonas maltophilia isolates were obtained from patients with nosocomial infection in the surgical wards and ICUs of six general hospitals in Tianjin, China. In vitro models of Stenotrophomonas maltophilia biofilms were established and confirmed by scanning electron microscopy and fluorescence microscopy with silver staining. The minimal inhibitory concentrations and biofilm inhibitory concentrations of commonly used antibiotics were determined. Results 47 of 51 strains were resistant to three or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Stenotrophomonas maltophilia; Biofilm; Antibiotic resistance; Nosocomial.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400365
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Antimicrobial susceptibility of quinupristin/dalfopristin tested against gram-positive cocci from Latin America: results from the Global SMART (GSMART) surveillance study BJID
Sader,Helio S.; Jones,Ronald N.; Ballow,Charles H.; Biedenbach,Douglas J.; Cereda,Rosangela F..
Gram-positive cocci are important causes of both nosocomial and community-acquired infections, and antimicrobial resistance among these pathogens has become an important problem worldwide. Since resistance among these organisms can vary substantially by geographic location, we conducted a multicenter surveillance study with isolates from five Latin American countries (15 medical centers). Quinupristin/dalfopristin (formerly RP-59500) is a novel streptogramin combination with focused activity against Gram-positive cocci, many exhibiting emerging resistance. The in vitro activity of quinupristin/dalfopristin and 12 other antimicrobial agents were evaluated against 1,948 strains including Staphylococcus aureus (747 strains), coagulase-negative staphylococci...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quinupristin/dalfopristin; Gram-positive cocci; SMART; Antimicrobial surveillance.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100004
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Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections BJID
Yu,Fangyou; Liu,Yunling; Lv,Jinnan; Qi,Xiuqin; Lu,Chaohui; Ding,Yu; Li,Dan; Liu,Huanle; Wang,Liangxing.
ABSTRACT A better understanding of the antimicrobial susceptibility, carriage of virulence determinants and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections (SSTIs) may provide further insights related to clinical outcomes with these infections. From January 2012 to September 2013, a total of 128 non-duplicateS. aureus isolates were recovered from patients with SSTIs. All 128 S. aureus SSTI isolates carried at least five virulence genes tested. Virulence genes detected among at least 70% of all tested isolates included hld (100%), hla (95.3%),icaA (96.9%), clf (99.2%),sdrC (79.7%), sdrD (70.3%), andsdrE (72.7%). The prevalence of MRSA isolates with 10 virulence genes tested (54.4%, 31/56) was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Staphylococcus aureus; Skin and soft tissue infections; Molecular characteristic; Virulence genes.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600614
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Antimicrobial therapy for community-acquired pneumonia in adults BJID
Cunha,Clovis Arns da; Sader,Helio S.; Nicodemo,Antonio C..
This is part of the series of practice guidelines commissioned by the Brazilian Society for Infectious Diseases through its Practice Guidelines Committee. The purpose of these guidelines is to provide assistance to clinicians in the antimicrobial treatment of community-acquired pneumonia (CAP) in immunocompetent adults. Panel members and consultants are experts in adult infectious diseases. The guidelines are evidence based where possible. The recommendations included in this document were elaborated based on the most frequently isolated pathogens and their antimicrobial susceptibilities. The etiology was based mainly on international studies, since there are very few regional data. On the other hand, the antimicrobial susceptibilities of main bacterial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Community-Acquired Pneumonia; Guidelines; Brazilian Society for Infectious Diseases.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200004
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Antimicrobials and renal failure in neutropenic patients BJID
França,Monique Sedlmaier; Lima,Stella Sala Soares; Duclou,Caroline Naback; Goulart,Eugênio Marcos Andrade; Romanelli,Roberta Maia de Castro.
Antimicrobial treatment is often indicated to neutropenic patients. Although renal failure is a common complication of many antibiotics, no information could be found in the literature defining which are the best screening criteria for detecting renal injury. In this paper, the authors aim to assess the progress to renal failure in neutropenic patients on antimicrobial use and to compare different diagnostic criteria of renal failure in association to antimicrobial agents used. This is a cohort study conducted from February to August 2006 at the Hospital das Clínicas of the Universidade Federal de Minas Gerais, which included patients with neutropenia and antimicrobial therapy for the treatment of Healthcare Associated Infections notified by the Hospital...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Neutropenia; Renal insufficiency; Antimicrobial agents.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400016
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Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro BJID
Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa.
Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155
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Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children BJID
El Beitune,Patrícia; Duarte,Geraldo; Quintana,Silvana Maria; Figueiró-Filho,Ernesto A.; Marcolin,Alessandra Cristina; Abduch,Renata.
Women have emerged as the fastest growing human immunodeficiency virus (HIV) infected population worldwide, mainly because of the increasing occurrence of heterosexual transmission. Most infected women are of reproductive age and one of the greatest concerns for both women and their physicians is that more than 1,600 infants become infected with HIV each day. Almost all infections are a result of mother-to-child transmission of HIV. With the advent of combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. Antiretroviral compounds differ from most other new pharmaceutical agents in that they have become widely prescribed in pregnancy in the absence of proof of safety. We reviewed antiretroviral agents...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1; Exposed; Infant; Consequences; Antiretroviral.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200004
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Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers BJID
Coelho,Antonio V.C.; Moura,Ronald R. de; Guimarães,Rafael L.; Brandão,Lucas A.C.; Crovella,Sergio.
ABSTRACT Background: Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving viral suppression. The genetic component of this condition is not yet completely elucidated. Objective: To identify predictive genetic markers of immune response to ART. Methods: Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1; Pharmacodynamics; Immunogenetics; Genetic association study; Survival analysis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500392
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Anti-Trypanosoma cruzi antibody detection in blood donors in the Southern Brazil BJID
Araújo,A.B.; Vianna,E.E.S.; Berne,M.E.A..
Trypanosoma cruzi, the causal agent of Chagas' Disease, is a widely spread protozoa in America. Blood transfusion is the secondly most important way of acquiring the infection. In blood banks, tests are performed to eliminate potentially infected blood. This study aimed to evaluate the positivity for T. cruzi in blood samples of donor's candidates in Southern Brazil. The study was based on a sampling containing all blood donors of Hemopel - a Pelotas City Blood Center, Rio Grande do Sul State, Brazil, from 2004 to 2005. Serological study was performed using ELISA Chagatest. Sampling containing values ± 20% cut off were evaluated using ELISA Chagatek, ELISA Alka/Adaltis, IHA Chagatest and IIF Imunocruzi. TESA-Blot was used as a confirmatory procedure in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Blood donors; Serological screening.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600007
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